Young blood promotes brain regeneration

On the “growing old is natural” vs “it should be medically reversed” debate, vampires have crossed the picket line from the get-go and scientists have just proven they may have been onto something.

THeir solution to the problem of ageing is clear; vampires suck juvenile blood to stay alive and regain their own youth. Stealing children to use as blood banks would probably scare off your friends and family but do vampires know something we don’t?

Recent scientific research suggests that we could reverse the ageing process using a newly identified biological molecule found in young blood that restores the regenerative capacity of old brains.

A signpost of getting old is a decline in our cognitive ability, mainly noticed by the worsening of our memory and a difficulty when trying to learn new things.

Our brains undergo this due to a reduction in neurogenesis, the process by which neural progenitor cells produce fresh neurons. Evidence suggests that when we age the number of these cells drop but epigenetic mediators are also thought to play a role in age-related regenerative decline.

Epigenetic mediators are molecules which cause the structure of DNA to change, resulting in altered gene expression. Within the last few years, research using heterochronic parabiosis studies (anatomically linking two animals) have shown that exposing aged individuals to young blood can lead to the rejuvenation of many functions in an ageing brain. In these studies, a young mouse’s vascular system is joined to an older mouse, exposing the older mouse to the younger blood.

A new study published in Cell Reports, identified Tet2 as an epigenetic enzyme, a chemical that can alter how genes are expressed and the proteins they produce. Tet2 can undergo regenerative decline and enhance certain cognitive functions in the adult mouse brain.

The infusion of young blood into adult mice caused Tet2 levels to increase in the hippocampus, the area of the brain involved in memory and learning. Tet2 is evolutionarily conserved between mice and humans and catalysed the oxidation of 5-methylcytosine to 5-hydroxy-methylcytosine, associated with age-related disorders such as stroke, cardiovascular diseases, and cancer.

The tag that Tet2 leaves on DNA has been shown to decline in the hippocampus with age, confirming that the DNA of young mice is regulated differently than older ones. Interestingly, the genes which are affected by this epigenetic change are the ones which have been previously associated with the process of neurogenesis.

Tet2 is clearly a key player in cognitive decline as young mice with inhibited Tet2 lost their ability to birth new neurons and perform simple memory tasks but mice with over-expressed Tet2 showed a significant improvement in memory tasks.

These findings show that Tet2 can rescue regenerate decline and enhance some cognitive functions in the adult mouse brain. Although ageing is something we will all go through, it can be rather ambiguous.If our brains remain healthy and able to continue neurogenesis, we would stay young forever even if your bodies wrinkle and ache, at least in theory.

What is of more scientific interest, however, is that targetting Tet2 could also lead to better therapies for treating neurological disorders such as Alzheimer’s and Parkinson’s disease.

It remains to be confirmed whether these findings are translatable to human systems but they do provide an exciting approach to targeting adult stem cell functions to rejuvenate regenerative capacity. So you can put your fangs away, for now.

Get the best viral stories straight into your inbox!

Don't worry, we don't spam

Leave a Reply

Join the Badger Team

Apply today!

Latest Posts

Union obliterates the debate – unwritten requirement used to shut down free speech debate
Campus News
722 views1
Campus News
722 views1

Union obliterates the debate – unwritten requirement used to shut down free speech debate

Jordan Wright - April 27, 2018

Student society Liberate the Debate’s most recent event was cancelled over a lack of compliance with the Students' Union's (USSU) requirement for a neutral chair - a…

Verve Couture – Musicality, kitsch & ignition: the beginning of a series
Arts
165 views
Arts
165 views

Verve Couture – Musicality, kitsch & ignition: the beginning of a series

Ricardo Reverón Blanco - June 17, 2018

Pictured: Zac Black At Proud Cabaret audiences were spellbound as if at night at the circus, yet this was not like Angela Carter’s magical realist novel; Verve…

Fleabag on stage at The Old Market – review
Arts
185 views
Arts
185 views

Fleabag on stage at The Old Market – review

Florence Dutton - June 11, 2018

[caption id="attachment_35513" align="alignnone" width="2400"] Fleabag at Soho Theatre[/caption] Last Monday at 8pm at Brighton’s The Old Market, I sat myself down in my theatre seat eagerly awaiting…

Fleabag preview
Arts
179 views
Arts
179 views

Fleabag preview

Florence Dutton - June 2, 2018

[caption id="attachment_35513" align="alignnone" width="2400"] Fleabag at Soho Theatre[/caption] Following the mass success of the Bafta award-winning BBC Series, DryWrite and Soho Theatre are about to hit the…

Brighton Festival: Ezra Furman at the Dome
Arts
221 views
Arts
221 views

Brighton Festival: Ezra Furman at the Dome

Georgia Grace - June 1, 2018

Having completed my final semester of university with modules on punk history and queer arts, it was fitting that I rounded off my end-of-assessment celebrations by attending…

Arts
224 views

The Tempest review

Georgia Grace - May 30, 2018

As the sun begins to set over Hove Green, tinnies of Red Stripe are cracked open, tartan blankets are strewn, and families tuck into their picnic hampers.…

A Glass Half Empty review
Arts
218 views
Arts
218 views

A Glass Half Empty review

Georgia Grace - May 27, 2018

For those of us coming to the end of another year of university study, the prospect of careers, marriages and babies may seem a long way off.…

DollyWould at The Old Market review
Arts
209 views
Arts
209 views

DollyWould at The Old Market review

Alex Hutson - May 27, 2018

Sh!t Theatre’s DollyWould is a hilarious, thoughtful and experimental performance piece. The award winning show has the Sh!t Theatre duo integrating comedy, storytelling, personal experience and music.…

UCU Launch Petition to End the ‘Hostile Environment’ at Sussex
Campus News
332 views
Campus News
332 views

UCU Launch Petition to End the ‘Hostile Environment’ at Sussex

Billie-Jean Johnson - May 26, 2018

The Sussex branch of the University and College Union (UCU) has launched a petition calling for Vice-Chancellor Adam Tickell to end the 'hostile environment' at Sussex. The…

Arts
170 views

Shakespeare in the sun – The Tempest preview

Georgia Grace - May 24, 2018

In a world of dystopian King Lears and female Hamlets, Shakespeare’s classics are constantly being reimagined for the modern day. There’s something oddly refreshing then about the…

Review: Nick Cave Double Bill at The Old Market (TOM’s Film Club)
Arts
462 views
Arts
462 views

Review: Nick Cave Double Bill at The Old Market (TOM’s Film Club)

Sophie Coppenhall - May 23, 2018

What a phenomenal contrast these two films present when watched side-by-side. In essence, together they are capable of tracing inner and outer metamorphoses of their subjects. The…

Dollywould at The Old Market preview
Arts
209 views
Arts
209 views

Dollywould at The Old Market preview

Alex Hutson - May 22, 2018

From the 22nd May - 25th May 2018 DollyWould will be showing at The Old Market. An exciting new show, presented by Sh!t Theatre, who won the…

Exhibition: Io-sono Fedilouu
Artist Focus
309 views
Artist Focus
309 views

Exhibition: Io-sono Fedilouu

Ricardo Reverón Blanco - May 16, 2018

Last week artist Fedilou made her debut exhibition in the downstairs space of Morelli Zorelli, a quaint vegan Italian restaurant in Hove, featuring a collection of intimate…

Interview with Philosophy faculty and COGS director Ron Chrisley
Interview
215 views
Interview
215 views

Interview with Philosophy faculty and COGS director Ron Chrisley

Nikolaos Manesis - May 15, 2018

Ron Chrisley is a Reader in Philosophy, on the faculty of the Sackler Centre for Consciousness Science, and is the director of COGS (Centre for Cognitive Science).…

Adam review
Arts
293 views
Arts
293 views

Adam review

Ketan Jha - May 13, 2018

If you have been a stranger to the stage this spring and decide to see one contemporary show, let it be Adam. This reviewer went in entirely…

Brighton Fringe Preview: Nick Cave Double Bill at The Old Market (TOM’s Film Club)
Arts
333 views
Arts
333 views

Brighton Fringe Preview: Nick Cave Double Bill at The Old Market (TOM’s Film Club)

Sophie Coppenhall - May 13, 2018

In celebration of iconic Brighton local, legendary alt-rock musician (and episodic actor) Nick Cave, TOM’s Film Club are hosting a double-bill screening of his films at The…

Whimsical fairy-tale meets class war – Standard: Elite review
Arts
371 views
Arts
371 views

Whimsical fairy-tale meets class war – Standard: Elite review

Georgia Grace - May 11, 2018

Meta-theatricality and interactivity are becoming all the more vogue in contemporary theatre, and in a world where the arts are becoming increasingly open and democratised, I find…

A Year of Art Society: The Best Picks
Artist Focus
269 views
Artist Focus
269 views

A Year of Art Society: The Best Picks

Alex Leissle - May 9, 2018

  [gallery type="slideshow" ids="35385,35386,35387,35388,35389,35390,35391,35392,35393,35394,35395,35396,35397,35398,35399,35400,35401,35402,35403,35404,35405,35406,35407,35408,35409,35410,35411"]

More Brit(ish) than ever: A review of Afua Hirsch at Brighton Festival
Books
281 views
Books
281 views

More Brit(ish) than ever: A review of Afua Hirsch at Brighton Festival

William Singh - May 9, 2018

Afua Hirsch’s 2018 book - part memoir, part polemic - provokes mixed feelings. So too did her discussion of the topic at this year’s Brighton Festival. Don’t…

Ethnic-bioweapons: between conspiracy and reality
Science
367 views
Science
367 views

Ethnic-bioweapons: between conspiracy and reality

Luke Richards - May 8, 2018

Bioweapons exist, while ethnic-bioweapons are whispered conspiracies. Pandemics can fairly hazardous to human life, the 1918 Flu Pandemic killed 20-50 million people. A man made pandemic could…

Breaking: Spring referenda results announced
News
338 views
News
338 views

Breaking: Spring referenda results announced

Jessica Hubbard - May 4, 2018

Students have voted to support the BDS (Boycott, Divestment and Sanctions) movement, reject Prevent and adopt new Gender Equality policies. Results for the Students' Union referenda were…